Refractory Depression Current Strategies and Future Directions Edited by Willem A. Nolen Psychiatric Centre Bloemendaal, The Hague, The Netherlands Joseph Zohar The Chaim Sheba Medical Center, Israel Steven P. Roose New York State Psychiatric Institute, New York, USA Jay D. Amsterdam Department of Psychiatry, University of Pennsylvania, USA As many as 30% of depressed patients fail to respond to conventional antidepressant therapy, and 15% may develop a chronic unremitting depression. A variety of pharmacological, biochemical and clinical factors may contribute to this situation. However, even after making allowances for these variables, a substantial number of patients remain refractory to treatment. This text offers the clinician a broad insight into the problem of refractory depression, providing new information on the adequacy of standard treatments and the major alternatives as well as reviews of a number of other possible alternatives for those patients remaining depressed. Finally, some future directions and developments are presented which may soon lead to a better understanding of the problem of refractory depression. Written by an international field of authors, the book will be of value to all researchers and clinicians in the field of psychiatry.

Depression and Physical Illness, the sixth volume from the Perspectives in Psychiatry series, has been comprehensively compiled by international authorities in the field of depression. Concentrating on the presentation, assessment, aetiology, management and prognosis of depressive disorders in physical illnesses ranging from AIDS and cancer to cardiovascular disease and arthritis, this new work is essential reading for all those involved in the treatment of depression. The well-respected and experienced editors, Mary Robertson and Cornelius Katona have covered all aspects of the practical and clinical management of depression from pregnancy and childbirth, through childhood, adolescence and into elderly life.

Political and social change during Woolf's lifetime led her to address the role of the state and the individual. Michael H. Whitworth shows how ideas and images from contemporary novelists, philosophers, theorists, and scientists fuelled her writing, and how critics, film-makers, and novelists have reinterpreted her work for later generations. - ;During Virginia Woolf's lifetime Britain's position in the world changed, and so did the outlook of its people. The Boer War and the First World War forced politicians and citizens alike to ask how far the power of the state extended into the lives of individuals; the rise of fascism provided one menacing answer. Woolf's experiments in fiction, and her unique position in the publishing world, allowed her to address such intersections of the public and the private. Michael H. Whitworth shows how ideas and images from contemporary novelists, philosophers, theorists, and scientists fuelled her writing, and how critics, film-makers, and novelists have reinterpreted her work for later generations. The book includes a chronology of Virginia Woolf's life and times, suggestions for further reading, websites, illustrations, and a comprehensive index. - ;this fine study...produces a fresh portrait of Woolf and her multi-faceted contributions to English letters. The book's presentation of modern British literary and cultural history makes it a rich resource for Woolf scholars and an illuminating introduction for students - Woolf Studies Annual, Volume 12 d

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